The Hotel San Luca, run by the Zuccari family, is elegant and sophisticated, featuring a warm and familiar atmosphere. The building's interior underwent a radical renovation. Consequently, the majority of what you will see is new, but the atmosphere is undoubtedly old world. The building most likely dates back to the mid-19th century. The style of the building was heavily influenced by the nearby Mattatoio, a former slaughterhouse designed by the great architect Ireneo Aleandri who also designed the city's Teatro Nuovo theatre and Traversa Interna (interior passageway). Of particular interest is the beautiful interior courtyard with the Holy Wellspring, accessible from a spacious gallery that is similar to a cloister.

As you enter the hotel, freshness and brightness will surround you: the natural light filters through the arcade that opens into the central courtyard and reflects on the room's pastel walls. In the hall, comfortable armchairs are arranged around an 18th-century fireplace and antique furnishings make guests feel right at home. Two canaries occupy an antique birdcage, which blends nicely with the background of pastel colours from the striking collection of 19th-century tureens on display.

The rooms are spacious, colourful, soundproof, and extremely clean, filled with amenities and featuring 2 meter-wide double beds. The large bathrooms are finished with Carrara marble, some offering whirlpool bathtubs and all including telephone, towel heater, and fogless mirror. The hotel is air-conditioned and drapery- and carpet-free. The building complies with all the current regulations.

In the courtyard, where breakfast and cocktails are served on warm weather days, stands a fountain with a stone tablet from 1601 hanging above. For many years the stone, bearing a Latin inscription, was covered with ivy but following the restoration it was made legible once again. The tablet bears the City of Spoleto's coat of arms, St. Ponziano on horseback and a depiction of Prospero Biscuri or Bisonti, the city's vice governor that had it placed there. Next to the tablet is a large stone lion head. Partially submerged in the waters from the spring, a spout of water continues to gush from the lion's mouth.